Ryan Reynolds reacts to Neil Patrick Harris as Deadpool, responding just days after Neil Patrick Harris was announced as the new voice in a virtual reality game, by delivering his trademark humor in a playful clip. The exchange centers around the upcoming Deadpool VR game for the Meta Quest 3, with Reynolds poking fun at Harris and referencing the actor’s breakout role in Doogie Howser, M.D.
Reynolds Delivers a Quick-Witted Response to Casting News
Following the announcement that Neil Patrick Harris would bring the iconic ‘merc with a mouth’ to life in Deadpool VR, Ryan Reynolds promptly released an 85-second parody video. The clip featured Reynolds playing up the aesthetic of Doogie Howser, M.D., typing at a computer with a voiceover that mimicked the sitcom’s unique style. Although he replicated the familiar tone, Reynolds’ content differed from the original show, which first aired in the 1980s and gained cult status over its four-season run.
As Reynolds entertained fans with his spin on Harris’s early career, his comedic monologue included the lines:
“Today I learned a lesson about buttholes they don’t teach you in medical school,”
—Ryan Reynolds
He continued,
“People who steal your signature role are the biggest buttholes of all.”
—Ryan Reynolds
The bit was playfully interrupted by Robyn Lively, known for her role as Michele—the love interest of Howser in multiple episodes—further nodding to the original sitcom.
Deadpool VR Brings New Voices and Action
The new Deadpool VR game, which will feature Neil Patrick Harris embodying Wade Wilson, was officially announced at the Summer Game Fest and is being developed for the Meta Quest 3. The game’s crisp combat mechanics and authentic humor have already impressed those who have glimpsed early demos.
Phil Therien, lead design manager at Twisted Pixel, shared his vision for the title:
“It’s really all about being the cool, all-encompassing Deadpool experience,”
—Phil Therien, Lead Design Manager at Twisted Pixel
Therien emphasized,
“He has the weapons, he’s got the wit, the humor, and his own trademark way to solve problems. We’ve got all that throughout our game, so really, we’ve been kind of bottled up like what it is like to be Deadpool in VR.”
—Phil Therien, Lead Design Manager at Twisted Pixel
In addition to Harris joining as the new voice, the game builds on the anticipation surrounding the upcoming Deadpool and Wolverine crossover, which Reynolds noted could have marked the end of Wade Wilson. The project marks Harris’s first time taking on the role in a major interactive media release.
Anticipation for Marvel’s Next Digital Adventure
Deadpool VR does not yet have a release date, but it is slated for the Meta Quest 3. The announcement comes as fans await details about other Marvel-related games as well as upcoming movies. Ryan Reynolds, whose portrayal of Deadpool has defined the character in recent years, continues to engage audiences even while passing the role to a fellow actor for this gaming experience.
The playful exchange and the arrival of Neil Patrick Harris as Deadpool signal a fresh direction for the franchise in virtual reality, ensuring fans and newcomers alike will experience the mercenary’s sarcasm and action in a whole new way.
