Monday, June 23, 2025

Ryan Reynolds Hilariously Reacts to Neil Patrick Harris Taking Over as Deadpool in VR Game

Ryan Reynolds reaction to Neil Patrick Harris Deadpool VR game surfaced after Harris was announced as the new voice behind Deadpool in the upcoming Marvel’s Deadpool VR, set for release later this year. This marks the first time someone other than Reynolds plays the beloved antihero, as Harris brings his own twist to the character for the Meta Quest platform.

Reynolds, known for portraying Deadpool for over a decade in blockbuster films, responded to the development by releasing a humorous video. In the video, Reynolds channels Doogie Howser, referencing Harris’ breakthrough television role, and playfully addresses the changing of the guard in the Deadpool universe.

New Game Puts Neil Patrick Harris in the Spotlight

Marvel’s Deadpool VR was featured at the Summer Game Fest, where fans learned that Harris would give voice to the wisecracking assassin. A teaser shows Harris’s Deadpool rampaging through chaotic scenes. The game is exclusive to Meta Quest 3 and 3S headsets, promising immersive VR action and signature Deadpool humor.

The narrative centers on Deadpool being hired by Mojo with the promise of vast riches, only for the Merc With The Mouth to quickly realize what a mistake he’s made. The story questions whether he can survive or thrive as the Mojoverse’s premier interdimensional streaming star.

Ryan Reynolds
Image of: Ryan Reynolds

The game’s description highlights intense combat and creative weapon upgrades, encouraging players to engage in brutal melee and ranged attacks while traversing elaborate environments. The experience is designed to deliver fast-paced gameplay and inventive, over-the-top action.

Highlights and Industry Reactions

Reynolds’s video response is marked by tongue-in-cheek humor and a competitive spirit. Dressed like Doogie Howser, he delivers a series of over-the-top remarks following the casting decision, indicating both jest and mock indignation. Robyn Lively, Reynolds’ real-life sister-in-law and a former co-star of Harris on the television show Howser, appears in the video with her own pointed reaction.

Marvel’s Deadpool VR is set for release later in 2024, offering fans a new take on a favorite Marvel Universe character and pushing the boundaries of VR experiences for superhero gaming.

Other game announcements have also made headlines recently. Marvel 1943: Rise Of Hydra has been postponed by a year, while an open-world Black Panther title was cancelled. Meanwhile, the Russo brothers have expressed interest in possibly creating an Avengers video game, and the next Avengers film is scheduled for a December 2026 release. The Wu-Tang Clan revealed a multiplayer action game, featuring music from DJ Just Blaze, described as

“This project is very much a love letter to hip-hop culture and to Wu in general,”

—Just Blaze, DJ and producer.

What Comes Next for Deadpool and Gaming Fans

With Neil Patrick Harris stepping into the role of Deadpool for Meta’s VR game, both long-time fans of Reynolds and newcomers will witness a fresh take on the Merc With The Mouth. The merging of star talent and VR technology marks a significant shift for superhero games, building anticipation for new stories, characters, and experiences. As Marvel and pop culture icons like Wu-Tang Clan enter the gaming world, the coming years promise unique collaborations and bold experimentation across genres.

Escape the turd-burger of late-stage capitalism and enter a world of VR magic,

—Neil Patrick Harris, Actor

Today, I learned a lesson about buttholes they don’t teach you in medical school,

—Ryan Reynolds, Actor

People who steal your signature role are the biggest buttholes of all.

—Ryan Reynolds, Actor

No, I don’t blame Meta Quest. Neil Patrick Harris is an amazing actor with the nurturing voice of an angel, but even though I haven’t hit puberty yet, I still know when you’re getting totally screwed.

—Ryan Reynolds, Actor

Feel what it’s like to go deep inside Deadpool in Marvel’s Deadpool VR, an original game developed exclusively for Meta Quest 3/3S,

—Marvel’s Deadpool VR Game Description

Contracted by Mojo, with the promise of making money, like a lot of money, Deadpool sets out to capture villains from the Marvel Universe. The Merc With The Mouth soon realises he shouldn’t have so hastily signed the contract.  Will he survive or thrive in his journey to become the Mojoverse’s most famous interdimensional streaming star?

—Marvel’s Deadpool VR Game Description

Marvel’s Deadpool VR blends savage ranged and melee combat with fast paced and uncompromising traversal. Defeat enemies with an upgradeable arsenal of weapons and discover stylish and creative ways to dismember anyone who stands in your way,

—Marvel’s Deadpool VR Game Description

This project is very much a love letter to hip-hop culture and to Wu in general,

—Just Blaze, DJ and producer

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