George Clooney has expressed enthusiasm for a potential cameo on the hit HBO Max medical drama The Pitt, saying he would team up with his former ER colleague Noah Wyle, if given the opportunity. The possibility of a George Clooney The Pitt cameo was discussed during a recent interview at the Jay Kelly premiere.
Clooney Discusses His Readiness for a Reunion
At 64, the Oscar-winning actor confirmed he is eager to collaborate with Noah Wyle again, referencing the strong working relationship they built during their time on NBC’s ER. Asked if he’d consider returning to a medical drama, Clooney responded without hesitation that he would do it “in a heartbeat.”
When speaking with Entertainment Tonight, Clooney clarified that he has not yet approached Wyle, who is now 54, about making an appearance on The Pitt. He emphasized his respect for Wyle’s ownership of the show and his desire not to disrupt the production, stating,
“[I haven’t] talked to him about being on the show because it is his show,”
– George Clooney, Actor.
He added,
“I don’t want to interrupt. But I am deeply proud of him, if I’m allowed to be proud of him.”
– George Clooney, Actor.
Praise for Noah Wyle and The Pitt’s Success
Clooney described The Pitt as a remarkable accomplishment for his longtime friend Noah Wyle, expressing admiration for both the show’s quality and Wyle’s leadership. He continued,
“What a beautiful show it is and what a great success it has been and what a fun thing to have him, you know, kind of continuing on in a tradition.”
– George Clooney, Actor.
Clooney and Wyle first gained recognition starring as Doug Ross and John Carter, respectively, from 1994 on ER. Clooney left the show in 1999, returning only for brief cameos in later seasons, while Wyle continued in his role for many years. Their professional and personal bonds have remained strong, as shown in several public appearances together.

Earlier this year, Clooney called The Pitt “so good” and noted on Late Night with Seth Meyers that he remains “really dear friends” with Wyle. During that appearance, Clooney commended Wyle:
“He is just the most honorable, talented young man, I get to say, because I’m an old man,”
– George Clooney, Actor.
“And I cannot be happier for his success on this show. The show is just a beautiful show, and he does just a great job with it.”
– George Clooney, Actor.
Friendship and Playful Rivalry Off Screen
When Seth Meyers joked that Wyle might need to brush up on medical terms for The Pitt, Clooney pointed out his co-star’s natural skill with dialogue:
“But he never had trouble. He always could do it. And I hated him for that.”
– George Clooney, Actor.
He quipped that “people should hate Noah” in good-natured jest, reflecting the friendly rivalry and camaraderie shared by the two actors.
Next Season for The Pitt
The Pitt is set to return for its second season in January on HBO Max, giving fans hope that a George Clooney The Pitt cameo could eventually become reality. As the show continues, the longstanding partnership and mutual admiration between Clooney and Wyle remain evident, keeping audiences excited for any possible reunion on screen.
